CST, 41915T, HLA-B (BC43) Mouse Monoclonal Antibody

Monoclonal Antibody for studying HLA-B. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, HLA-B (BC43) Mouse Monoclonal Antibody (CST #41915) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:50 - 1:200 Storage Supplied in a PBS-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody . Note: This product is only available in the format listed above. We are unable to provide this in a carrier free, custom formulation. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity HLA-B (BC43) Mouse Monoclonal Antibody recognizes endogenous levels of HLA-B protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to specific amino acids in the N-terminal region of HLA-B protein. Background The human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell surface proteins are responsible for the regulation of antigen-specific immunity in humans. genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8 T lymphocytes to activate a cytotoxic T cell response (1,2). HLA-B (major histocompatibility complex, class I, B) is a heterodimer consisting of a heavy chain and light chain (beta-2 microglobulin) and is the most polymorphic of the genes (3). HLA-B is expressed in nearly all cells, and variations of the gene have been associated with hundreds of diseases and conditions (4). Alternate Names AS; B-4901; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA-B; HLAB; Human leukocyte antigen B; leukocyte antigen class I-B; major histocompatibility complex, class I, B; MHC class 1 antigen; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: IgG1 kappa