CST, 41983T, MNX1/HB9 (E3W8D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MNX1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MNX1/HB9 (E3W8D) Rabbit Monoclonal Antibody (CST #41983) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MNX1/HB9 (E3W8D) Rabbit Monoclonal Antibody recognizes endogenous levels of total MNX1/HB9 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser231 of human MNX1/HB9 protein. Background Motor neuron and pancreas homeobox protein 1 (MNX1 or Homeobox protein HB9) is a homeobox transcription factor that has conserved functions in motor neuron differentiation and pancreas development. The mammalian central nervous system (CNS) is composed of specialized neurons, and the Specification of neuronal identity in the CNS is determined early in development by spatially-specified expression of cell-intrinsic determinants, many of which are transcription factors (1). MNX1/HB9 is one such transcription factor. In response to developmental signals, MNX1/HB9 is expressed transiently to drive differentiation of ventral progenitor cells into somatic motor neurons (2,3). Mutations in the gene encoding human MNX1/HB9 are linked to Currarino syndrome, a developmental disease caused by dorsal-ventral patterning defects resulting in presacral tumors, sacral agenesis, and anorectal malformation in patients suffering from this disease (4,5).  Alternate Names HB9; HLXB9; homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; motor neuron and pancreas homeobox 1; Motor neuron and pancreas homeobox protein 1; SCRA1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 55 Source/Isotype: Rabbit IgG