CST, 4229S, Dexras1 Antibody

Polyclonal Antibody for studying RASD1. Validated for Western Blotting. Highly specific and rigorously validated in-house, Dexras1 Antibody (CST #4229) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Dexras1 Antibody detects endogenous levels of total Dexras1 protein. This antibody also cross-reacts with a 60 kDa protein of unknown origin. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Dexras1 protein. Antibodies were purified by protein A and peptide affinity chromatography. Background Dexras1 (Ras dexamethasone induced 1) belongs to the Ras superfamily of GTPases and was initially identified as a dexamethasone inducible gene (1,2). Dexras1 reportedly regulates several distinct signal transduction pathways, including MAPK signaling, NMDA receptor-nitric oxide-mediated signaling, and pathways involving adenylyl cyclases (3-5). Dexras1 can directly modulate FE65-APP-mediated transcription and regulate the photic sensitivity of the mammalian circadian clock (6,7). Alternate Names activator of G protein signaling; Activator of G-protein signaling 1; AGS1; Dexamethasone-induced Ras-related protein 1; DEXRAS1; MGC:26290; ras related dexamethasone induced 1; ras-related protein; RAS, dexamethasone-induced 1; RASD1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 30 SOURCE: Rabbit