CST, 42437S, Cav2.3/CACNA1E Antibody

Polyclonal Antibody for studying CACNA1E mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, Cav2.3/CACNA1E Antibody (CST #42437) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Cav2.3/CACNA1E Antibody recognizes endogenous levels of total Cav2.3 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1039 of mouse Cav2.3 protein. Antibodies are purified by peptide affinity chromatography. Background Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 is encoded by the gene (1,2). In the brain, Cav2.3 has been implicated in synaptic plasticity (3,4). Interestingly, Cav2.3 may contribute to some neurodegenerative diseases like Parkinson's disease (5). Alternate Names A430040I15; alp; alpha1E; BII; Brain calcium channel II; CAC1E; Cach6; Cacna1e; Cacnl1a6; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; Cav2; Cav2.3; Cchr; Cchra1; Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-gated calcium channel subunit alpha Cav2.3 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 257 SOURCE: Rabbit