CST, 4335T, CD105/Endoglin (D50G1) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CD105/endoglin. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CD105/Endoglin (D50G1) Rabbit Monoclonal Antibody (CST #4335) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CD105/Endoglin (D50G1) Rabbit Monoclonal Antibody detects endogenous levels of total CD105/Endoglin protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala463 of human CD105/Endoglin protein. Background CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and endothelial and stromal cells. Upregulated CD105/Endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). Alternate Names CD105; CD105 antigen; EGLN; END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 95 Source/Isotype: Rabbit IgG