CST, 43514S, CD141/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CD141. Validated for WB,IP,IHC,IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, CD141/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody (CST #43514) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:200 IHC Leica Bond: 1:100 - 1:400 Immunohistochemistry (Paraffin): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 34149 . Protocol Available protocols: Western Blotting, Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin) Specificity / Sensitivity CD141/Thrombomodulin (E7Y9P) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD141/Thrombomodulin protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with human CD141/Thrombomodulin recombinant protein. Background CD141/Thrombomodulin (TM, THBD, BDCA-3) is an integral membrane protein expressed on the surface of endothelial cells (1). Acting as a cofactor with Thrombin, CD141/Thrombomodulin activates and initiates the Protein C anticoagulant pathway (1,2). CD141/Thrombomodulin is expressed by a small subset of human CD11c+ myeloid dendritic cells (3-4). These CD141+XCR1+ dendritic cells cross-present antigens to naïve CD8+ T cells, priming them to become activated cytotoxic CD8+ T cells (3-5). Alternate Names AHUS6; BDCA3; CD141; CD141 antigen; Fetomodulin; THBD; THPH12; THRM; Thrombomodulin; TM; TRBM Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 90 Source/Isotype: Rabbit IgG