CST, 43562V2, PathScan® RP CRBN Sandwich ELISA Kit

ELISA Kit for studying CRBN in the research area. Protocol Available protocols: ELISA+ Specificity / Sensitivity The PathScan Species Reactivity: Human, Mouse, Rat Background CRBN/Cereblon, a substrate receptor for the CRL4 E3 ubiquitin ligase, was originally identified for its role in autosomal recessive nonsyndromic mental retardation (1). CRBN's role in the regulation of the AMPK pathway has been linked to various human diseases, including cardiovascular disease and obesity, and its involvement in proteasomal degradation may be important in neuropsychiatric diseases (2). CRBN has also been shown to enhance the effects of immunomodulatory imide drugs (IMiDs) in multiple myeloma, and may be a predictive marker for therapy (2-4). Alternate Names cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; Protein cereblon; protein x 0001 Specification REACTIVITY: H M R