CST, 43603T, Cyclophilin B (D1V5J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PPIB. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, Cyclophilin B (D1V5J) Rabbit Monoclonal Antibody (CST #43603) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Cyclophilin B (D1V5J) Rabbit Monoclonal Antibody recognizes endogenous levels of total cyclophilin B protein. This antibody does not cross-react with cyclophilin A protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human cyclophilin B protein. Background Cyclophilin B (CyPB) is an ER-localized chaperone protein belonging to the family of peptidyl-prolyl cis-trans isomerases (PPIases) (1,2). Research studies have demonstrated that CyPB associates with type I procollagen and is involved in its sorting and transport through the secretory compartment (3). Mutations in the gene encoding CyPB, , lead to aberrant biosynthesis of type I procollagen, which underlies the pathogenesis of osteogenesis imperfecta (OI), a disorder characterized by bone fragility (4-7). In additional to its role in OI, research studies demonstrate that CyPB overexpression supports the expression of multiple oncogenic drivers of glioblastoma multiforme (8). Alternate Names B; Cyclophilin B; cyclophilin-like protein; CYP-S1; CYPB; epididymis secretory protein Li 39; HEL-S-39; MGC14109; MGC2224; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; PPIB; Rotamase B; S-cyclophilin; SCYLP Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 20 Source/Isotype: Rabbit IgG