CST, 4403S, TWEAK Receptor/Fn14 Antibody

Polyclonal Antibody for studying TweakR. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, TWEAK Receptor/Fn14 Antibody (CST #4403) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TWEAK Receptor/Fn14 Antibody detects endogenous levels of total TWEAK Receptor/Fn14 protein. Species Reactivity: Human, Mouse, Rat, Bovine Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of the TWEAK Receptor/Fn14. Antibodies were purified by protein A and peptide affinity chromatography. Background The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggested some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9). Alternate Names CD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; FN14; TNF receptor superfamily member 12A; TNFRSF12A; TNR12; Tumor necrosis factor receptor superfamily member 12A; Tweak-receptor; tweak-receptor; type I transmembrane protein Fn14; TweakR; type I transmembrane protein Fn14 Specification REACTIVITY: H M R B SENSITIVITY: Endogenous MW (kDa): 14-17 SOURCE: Rabbit