CST, 44462S, PTMScan® Nitro-Tyrosine Motif [Nitro-Y] Kit

PTMScan for studying in the research area. Storage Antibody beads supplied in IAP buffer containing 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: PTMScan Background Nitric oxide (NO) is implicated in carcinogenesis (1), chronic infection, inflammation (2), and neurodegeneration (3). High levels of both superoxide and NO in tissues interact to form peroxynitrite, a potent oxidant that can modify Tyr residues in proteins to form 3-nitro-tyrosine (4). Tyrosine nitration of mitochondrial manganese superoxide dismutase results in loss of enzymatic activity (4). The nitration of p53 at Tyr residues abolishes its capacity for binding to its DNA consensus sequence (5). Alternate Names 3-nitrotyrosine; 3NT; Nitro-Y; Nitrosylation; nitrotyrosine; NO2Y; Tyrosine nitration; Y-NO2