CST, 4464S, Hop Antibody

Polyclonal Antibody for studying HOP. Validated for Western Blotting. Highly specific and rigorously validated in-house, Hop Antibody (CST #4464) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Hop Antibody detects endogenous levels of total Hop protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human Hop. Antibodies are purified by protein A and peptide affinity chromatography. Background HOP, also known as stress-induced phospho protein 1 (STIP), is a co-chaperone to the major heat shock proteins, Hsp70 and Hsp90, and appears in early receptor complexes (1,2). Through mutual binding to both Hsp70 and Hsp90, Hop functions as an adaptor that can integrate Hsp70 and Hsp90 interactions (3,4). HOP is an abundant and highly conserved protein which is composed of three tetratricopeptide repeat (TPR) domains (TPR1, TPR2a and TPR2b) and two DP repeat domains (DP1 and DP2), whose function has not been fully resolved (5). Alternate Names epididymis secretory sperm binding protein Li 94n; HEL-S-94n; Hop; Hsc70/Hsp90-organizing protein; Hsp70/Hsp90-organizing protein; IEF-SSP-3521; NY-REN-11 antigen; P60; Renal carcinoma antigen NY-REN-11; STI1; STI1L; STIP1; stress induced phosphoprotein 1; Stress-induced-phosphoprotein 1; stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein); Transformation-sensitive protein IEF SSP 3521 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 64 SOURCE: Rabbit