CST, 44796S, TYRP1 (F6Y6N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TYRP1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, TYRP1 (F6Y6N) Rabbit Monoclonal Antibody (CST #44796) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TYRP1 (F6Y6N) Rabbit Monoclonal Antibody recognizes endogenous levels of total TYRP1 protein. This antibody does not cross-react with TYR or DCT/TYRP2 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly83 of human TYRP1 protein. Background Tyrosinase-related protein 1 (TYRP1) is a highly glycosylated transmembrane, zinc-binding metalloenzyme that belongs to the tyrosinase family. TYRP1 expression promotes melanogenesis and is highly localized to the melanosomal subcellular compartment of skin and retinal pigment epithelium melanocytes in normal tissues (1-3). Research studies have demonstrated that TYRP1 is highly expressed in human melanomas and has been identified as a candidate target of immunotherapeutic modalities given its tissue-restricted expression pattern (4-6). Alternate Names 5,6-dihydroxyindole-2-carboxylic acid oxidase; b-PROTEIN; CAS2; Catalase B; CATB; DHICA oxidase; Glycoprotein 75; GP75; Melanoma antigen gp75; OCA3; TRP; TRP-1; TRP1; tyrosinase related protein 1; Tyrosinase-related protein 1; TYRP; TYRP1; TYRRP Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 75 Source/Isotype: Rabbit IgG