CST, 44830S, TEX264 (E2J3J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TEX264. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TEX264 (E2J3J) Rabbit Monoclonal Antibody (CST #44830) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TEX264 (E2J3J) Rabbit Monoclonal Antibody recognizes endogenous levels of total TEX264 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro193 of human TEX264 protein. Background TEX264 (testis expressed gene 264) is a single-pass transmembrane protein localized to the endoplasmic reticulum (ER) that plays a key role in the clearance of damaged ER via the selective autophagic process of ER-phagy (1,2). It contains an LC3 interacting region (LIR) acting as a bridge from the ER to Atg8 family members, LC3 and GABARAP, on the autophagosome. Phosphorylation of TEX264 by casein kinase 2 can enhance its interaction with Atg8 family members (3). TEX264-mediated ER-phagy has been observed in pathological conditions, including acetaminophen-induced hepatotoxicity and in neuroinflammation associated with Alzheimer's Disease (4,5). TEX264 has also been found to contribute to genomic stability through association with the VCP ATPase promoting TOP1-mediated DNA repair (6). Alternate Names DKFZp451H0417; FLJ13935; Putative secreted protein Zsig11; SIG11; testis expressed 264; testis expressed 264, ER-phagy receptor; testis expressed gene 264; testis expressed sequence 264; Testis-expressed protein 264; Testis-expressed sequence 264 protein; TEX264; TX264; ZSIG11 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 45 Source/Isotype: Rabbit IgG