CST, 44956S, Catalase (D4P7B) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)

Monoclonal Antibody for studying Catalase. Validated for Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, Catalase (D4P7B) Rabbit Monoclonal Antibody (Alexa Fluor^® 647 Conjugate) (CST #44956) is ready to ship. Product Usage Information Immunofluorescence (Immunocytochemistry): 1:400 - 1:800 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity Catalase (D4P7B) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human catalase protein. Background Catalase catalyzes the conversion of hydrogen peroxide to water and oxygen (1). Research studies show that overexpression of this antioxidant enzyme increases the ability of pancreatic β-cells to scavenge reactive oxygen species (ROS), thereby protecting pancreatic β-cells from oxidative stress (2). The pancreatic β-cells overexpressing this enzyme are also protected from hydrogen peroxide-mediated lipotoxicity, providing further evidence for the importance of catalase in the pathogenesis of diabetes (3). Alternate Names CAT; CATA; Catalase; epididymis secretory sperm binding protein; MGC138422; MGC138424 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG