CST, 45268S, MOG (D5B4C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MOG. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, MOG (D5B4C) Rabbit Monoclonal Antibody (CST #45268) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Immunofluorescence (Frozen): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 36647 . Protocol Available protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Frozen) Specificity / Sensitivity MOG (D5B4C) Rabbit Monoclonal Antibody recognizes endogenous levels of total MOG protein. This antibody cross-reacts with other human MOG isoforms that contain the carboxy terminus of human MOG isoform 1. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MOG protein. Background Myelin-oligodendrocyte glycoprotein (MOG) is a type I membrane bound glycoprotein of the immunoglobulin superfamily that is enriched in the outer lamella of the myelin sheath (1). The myelin sheath is a multi-layered membrane structure composed of oligodendrocytes that increases the conduction velocity of axonal impulses. The specific function of MOG is unknown, but MOG's structure and expression during later stages of myelinogenesis suggests a role in myelin sheath maturation and maintenance (2). MOG may be an autoimmune target in central nervous system inflammatory diseases such as multiple sclerosis (MS) (3). Induction of MOG autoimmunity is also used as an experimental model for MS as injections of MOG peptide or recombinant protein in rodent models causes severe neurological disease that recapitulates several clinical features of MS (4). Alternate Names BTN6; BTNL11; MGC26137; MOG; MOG alpha-5; MOG AluA; MOG AluB; MOG Ig-AluB; MOGIG2; myelin oligodendrocyte glycoprotein; Myelin-oligodendrocyte glycoprotein; NRCLP7 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 46, 35, 28, 23, 14 Source/Isotype: Rabbit IgG