CST, 45535S, Perilipin-2 Antibody

Polyclonal Antibody for studying perilipin 2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Perilipin-2 Antibody (CST #45535) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Perilipin-2 Antibody recognizes endogenous levels of total perilipin-2 protein. This antibody does not cross-react with perilipin-1 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human perilipin-2 protein. Antibodies are purified by peptide affinity chromatography. Background Eukaryotic cells store lipids in lipid droplets. These intracellular lipid storage structures are covered by members of the perilipin family of lipid droplet coat proteins. Perilipins establish an interface between stored lipids and the cytosol and coordinate lipid storage and utilization (1-3). Mice deficient of perilipin-2 have decreased levels of triglycerides in the liver and are protected from fatty liver disease. In addition, these mice show increased autophagy in the liver. In contrast, overexpression of perilipin-2 protects lipid droplets from autophagy (4). Alternate Names ADFP; Adipophilin; Adipose differentiation-related protein; ADRP; MGC10598; perilipin 2; Perilipin-2; PLIN2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 52 SOURCE: Rabbit