CST, 45948T, TIMM17A (E6F3I) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TIMM17A. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TIMM17A (E6F3I) Rabbit Monoclonal Antibody (CST #45948) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TIMM17A (E6F3I) Rabbit Monoclonal Antibody recognizes endogenous levels of total TIMM17A protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro160 of human TIMM17A protein. Background TIMM17A (mitochondrial import inner membrane translocase subunit Tim17-A) is a component of the TIM23 mitochondrial transport complex, the main translocase of mitochondrial matrix proteins (1). TIMM17A is a potential biomarker and therapeutic target in breast cancer, as high expression is associated with aggressiveness and poor prognosis (2-4). was identified as one of eleven genes included in a gene signature predictive of CDK4 phosphorylation, and of sensitivity to the CDK4/6 inhibitor Palbociclib (5). Alternate Names Inner membrane preprotein translocase Tim17a; MIMT17; Mitochondrial import inner membrane translocase subunit Tim17-A; mitochondrial inner membrane translocase; preprotein translocase; TI17A; TIM17; TIM17A; TIMM17; TIMM17A; translocase of inner mitochondrial membrane 17 homolog A; translocase of inner mitochondrial membrane 17A Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 18 Source/Isotype: Rabbit IgG