CST, 4595S, GATA-2 Antibody

Polyclonal Antibody for studying GATA2. Validated for Western Blotting. Highly specific and rigorously validated in-house, GATA-2 Antibody (CST #4595) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity GATA-2 Antibody detects endogenous levels of total GATA-2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser277 of human GATA-2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background The zinc finger transcription factor GATA-2 is widely expressed and plays an essential role in many developmental processes (1). Studies on GATA-2 knockout mice indicate that this protein is required in hematopoiesis (2). GATA-2 also inhibits the differentiation of white (3) and brown adipocytes (4) and has been shown to suppress the proliferation of neuronal progenitor cells (5). Alternate Names DCML; Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; IMD21; MGC2306; MONOMAC; NFE1B Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 51 SOURCE: Rabbit