CST, 46003T, ZDHHC24 (F9U2B) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ZDHHC24. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ZDHHC24 (F9U2B) Rabbit Monoclonal Antibody (CST #46003) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity ZDHHC24 (F9U2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZDHHC24 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ZDHHC24 protein. Background Palmitoylation, also known as S-acylation, is a posttranslational modification characterized by the reversible addition of fatty acids onto cysteine residues (1). Palmitoylation is typically carried out by a family of transmembrane enzymes known as zinc finger DHHC domain-containing (ZDHHC) proteins (2). One family member in particular, ZDHHC24, has been shown to palmitoylate mitochondrial antiviral signaling protein (MAVS), consequently activating the TBK1-IRF3-interferon (IFN) pathway and promoting antiviral immune responses (3). Alternate Names DHHC-24; Probable palmitoyltransferase ZDHHC24; ZDH24; ZDHHC24; Zinc finger DHHC domain-containing protein 24; zinc finger DHHC-type containing 24; zinc finger, DHHC domain containing 24; zinc finger, DHHC-type containing 24 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 25 Source/Isotype: Rabbit IgG