CST, 46764S, CD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor® 488 Conjugate)

Monoclonal Antibody for studying CD38 mouse. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, CD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor^® 488 Conjugate) (CST #46764) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:50 - 1:200 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity CD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro298 of mouse CD38 protein. Background Cyclic ADP-ribose hydrolase 1 (CD38) is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD (1,2). Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) from NADP . Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca stores (3-6). Since CD38 is the primary mammalian NAD glycohydrolase responsible for NAD metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD -dependent pathways (7,8). CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia (9-11). Alternate Names 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr hydrolase 1; Cd38; CD38 antigen; Cd38-r; Cd38-rs1; Cyclic ADP-ribose hydrolase 1; I-19; NIM-R5 antigen Specification REACTIVITY: M R SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG