CST, 46894T, CD37 (E4K2M) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CD37. Validated for Western Blotting,Immunoprecipitation,Flow Cytometry (Live). Available in 2 sizes. Highly specific and rigorously validated in-house, CD37 (E4K2M) Rabbit Monoclonal Antibody (CST #46894) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Flow Cytometry (Live): 1:400 - 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Western Blotting, Immunoprecipitation, Flow Cytometry (Live) Specificity / Sensitivity CD37 (E4K2M) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD37 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to an extracellular domain of human CD37 protein. Background CD37 belongs to the tetraspanin family of transmembrane proteins and a high level of expression is restricted largely to normal and as well as malignant B cells. Other immune cell populations such as T cells and monocytes, however, have been shown to express low levels of CD37 (1). While the molecular mechanisms are still not fully resolved, research studies have shown that CD37 becomes tyrosine phosphorylated and facilitates association with intracellular signaling proteins that drive both survival and apoptosis in B cells (2). Due to its fairly restricted, high level of expression in normal and neoplastic B cells, CD37 has become an attractive immunotherapy target in the context of B cells malignancies (3,4). Alternate Names CD37; CD37 antigen; CD37 molecule; cell differentiation antigen 37; GP52-40; Leukocyte antigen CD37; leukocyte surface antigen CD37; MGC120234; Tetraspanin-26; Tspan-26; TSPAN26 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 40-50 Source/Isotype: Rabbit IgG