CST, 46905S, SRSF10 (E9A6K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SRSF10. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, SRSF10 (E9A6K) Rabbit Monoclonal Antibody (CST #46905) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunofluorescence (Immunocytochemistry): 1:50 - 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity SRSF10 (E9A6K) Rabbit Monoclonal Antibody recognizes endogenous levels of total SRSF10 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His167 of human SRSF10 protein. Background Serine/arginine-rich splicing factor 10 (SRSF10), also known as TASR or SRp38, was initially described as a splicing factor associated with the FUS oncoprotein (1,2). Upon dephosphorylation, SRSF10 represses splicing to regulate numerous functions, including cell cycle, heat shock response, neurogenesis, and adipocyte differentiation (3-6). SRSF10 is affected by adenosine methylation, as it has been shown to be excluded from nuclear speckles by m6A-binding protein YTHDC1 (7). SRSF10 splicing repression has been implicated in colon and cervical cancer (8,9). Alternate Names 40 kDa SR-repressor protein; DKFZp686H0644; FLJ30749; FLJ43846; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; FUSIP1; FUSIP2; neural-salient SR protein; NSSR; PPP1R149; protein phosphatase 1, regulatory subunit 149; serine and arginine rich splicing factor 10; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; SF13A; SFRS13; SFRS13A; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR splicing factor 10; SRp38; SRrp40; SRS10; SRSF10; TASR; TASR1; TASR2; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 40 Source/Isotype: Rabbit IgG