CST, 47188S, ZIP8/SLC39A8 (E3V8K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SLC39A8. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, ZIP8/SLC39A8 (E3V8K) Rabbit Monoclonal Antibody (CST #47188) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Immunofluorescence (Immunocytochemistry): 1:1600 - 1:3200 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity ZIP8/SLC39A8 (E3V8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZIP8/SLC39A8 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala265 of human ZIP8/SLC39A8 protein. Background Zinc transporter zinc-and iron-related protein 8 (ZIP8) is encoded by the gene and is a member of the solute carrier gene (SLC) superfamily (1). As a membrane protein, ZIP8 functions to transport manganese, cadmium, and zinc across the plasma membrane (2). Metal ions are essential elements that are required cofactors for proteins, including enzymes and transcription factors. Maintenance of proper metal ion homeostasis is required for normal mammalian tissue development and function. Mice lacking reveal a critical role of ZIP8 in organogenesis in multiple tissues, including the brain and kidney, during development (3,4). Mutations in are linked to autosomal-recessive forms of intellectual disability, suggesting that altered ZIP8-dependent metal ion regulation may contribute to human neuronal developmental diseases (5). Alternate Names BCG induced integral membrane protein BIGM103; BCG-induced integral membrane protein in monocyte clone 103 protein; BIGM103; CDG2N; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Metal cation symporter ZIP8; PP3105; S39A8; SLC39A8; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; Zinc transporter ZIP8; ZIP-8; ZIP8; Zrt- and Irt-like protein 8 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 65, 130 Source/Isotype: Rabbit IgG