CST, 47193S, POMC (AH26) Mouse Monoclonal Antibody

Monoclonal Antibody for studying POMC. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, POMC (AH26) Mouse Monoclonal Antibody (CST #47193) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:800 - 1:3200 Storage Supplied in 10 mM PBS containing 0.05% BSA and 0.05% sodium azide. Stable for 36 months when stored at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles . A slight precipitate may be present, but will not interfere with antibody performance. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity POMC (AH26) Mouse Monoclonal Antibody recognizes endogenous levels of total POMC protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino acids 1-24 of human POMC protein. Background Pro-opiomelanocortin (POMC) is a precursor protein expressed in the pituitary and the brain where it is processed into several peptide hormones and neuropeptides. Among these peptides are ACTH, α- and β-MSH, β-and γ-LPH, CLIP, β-endorphin, and N-POMC (1). POMC is involved in hypothalamic circuits regulating feeding behavior and POMC-producing neurons promote satiety (2). POMC neurons are also the target of leptin and insulin for the promotion of the browning of white fat (3). Alternate Names ACTH; Adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte-stimulating hormone; Alpha-MSH; Beta-endorphin; Beta-LPH; beta-melanocyte-stimulating hormone; Beta-MSH; CLIP; COLI; Corticotropin; Corticotropin-like intermediary peptide; Corticotropin-lipotropin; Gamma-LPH; Gamma-MSH; Lipotropin beta; Lipotropin gamma; LPH; Melanocyte-stimulating hormone alpha; Melanocyte-stimulating hormone beta; Melanotropin alpha; Melanotropin beta; Melanotropin gamma; Met-enkephalin; MSH; NPP; OBAIRH; opiomelanocortin prepropeptide; POC; POMC; Potential peptide; pro-ACTH-endorphin; Pro-opiomelanocortin; proopiomelanocortin; proopiomelanocortin preproprotein Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1 kappa