CST, 47500T, LRRC31 (F7I7Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LRRC31. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LRRC31 (F7I7Z) Rabbit Monoclonal Antibody (CST #47500) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LRRC31 (F7I7Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total LRRC31 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LRRC31 protein. Background Leucine-rich repeat-containing protein 31 (LRRC31) belongs to the LRR superfamily, which plays an important role in cell cycle regulation, chromosome stability, apoptosis, and DNA repair (1,2). LRRC31 functions as a tumor suppressor in cancer development. In lung adenocarcinoma (LUAD), β-hydroxybutyrate dehydrogenase 1 (BDH1) promotes LUAD progression through downregulation of LRRC31 expression (3). During breast cancer metastasis to the brain, LRRC31 functions as a DNA repair inhibitor through interaction with Ku70/Ku80 and ATR, sensitizing tumor metastasis to radiation therapy (4). In eosinophilic esophagitis (EoE), IL-13 upregulates LRRC31 expression, promoting epithelial barrier function by downregulating kallikrein expression (5). LRRC31 has also been identified as a novel regulator of pluripotency maintenance in mouse embryonic stem cells (mESCs) by facilitating Stat3 phosphorylation in the Jak/Stat signaling pathway (6). Alternate Names epididymis secretory protein Li 293; epididymis secretory sperm binding protein; FLJ23259; FLJ40019; HEL-S-293; leucine rich repeat containing 31; Leucine-rich repeat-containing protein 31; LRC31; LRRC31 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 60, 53 Source/Isotype: Rabbit IgG