CST, 47881S, JunB (C37F9) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3069)

Monoclonal Antibody for studying JunB. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, JunB (C37F9) Rabbit Monoclonal Antibody (InTraSeq^™ 3' Conjugate 3069) (CST #47881) is ready to ship. Storage Supplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Single Cell Analysis - InTraSeq™ 3' Specificity / Sensitivity JunB (C37F9) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3069) detects endogenous levels of total JunB protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro169 of human JunB. Background JunB is a basic region, leucine zipper (bZIP) transcription factor belonging to the Jun family that includes c-Jun and JunD. Jun family members homodimerize or heterodimerize with Fos and ATF proteins to form a functional transcription factor AP-1 (activator protein 1), whose activity is regulated by a variety of physiological and pathological stimuli such as growth factors, infections, and stress signals (1-4). While JunB sometimes antagonizes c-Jun transcriptional activity, it may functionally substitute for c-Jun during development in mice (5-7). JunB regulates hematopoietic stem cell number and plays an important role in the pathogenesis of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) (8,9). Alternate Names activator protein 1; AP-1; jun B proto-oncogene; JUNB; JunB proto-oncogene, AP-1 transcription factor subunit; Transcription factor jun-B; Transcription factor JunB Specification REACTIVITY: H M SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG