CST, 47988S, TNFRSF17/BCMA Antibody

Polyclonal Antibody for studying TNFRSF17. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, TNFRSF17/BCMA Antibody (CST #47988) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TNFRSF17/BCMA Antibody recognizes endogenous levels of total TNFRSF17/BCMA protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein. Antibodies are purified by protein A and peptide affinity chromatography. Background B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10). Alternate Names B cell maturation antigen; B-cell maturation factor; B-cell maturation protein; BCM; BCMA; CD269; TNF receptor superfamily member 17; TNFRSF13A; TNFRSF17; TNR17; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily, member 17 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 18, 23 SOURCE: Rabbit