CST, 48352S, CD206/MRC1 (E2L9N) Rabbit Monoclonal Antibody (Alexa Fluor® 555 Conjugate)

Monoclonal Antibody for studying MRC1. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, CD206/MRC1 (E2L9N) Rabbit Monoclonal Antibody (Alexa Fluor^® 555 Conjugate) (CST #48352) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity CD206/MRC1 (E2L9N) Rabbit Monoclonal Antibody (Alexa Fluor Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant human CD206/MRC1 protein. Background The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages, and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose, or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection, and trafficking through lymphatic vessels (9-12). The mannose receptor is a marker for M2 macrophages (13). Alternate Names bA541I19.1; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; CD206; CLEC13D; CLEC13DL; hMR; Human mannose receptor; Macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; Mannose receptor; mannose receptor C type 1; mannose receptor C-type 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; MMR; MRC1; MRC1L1 Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Rabbit IgG