CST, 48475S, PILRA (E7K1H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PILRA. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PILRA (E7K1H) Rabbit Monoclonal Antibody (CST #48475) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PILRA (E7K1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total PILRA protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro245 of human PILRA protein. Background Paired immunoglobulin-like type 2 receptor alpha (PILRA) is an inhibitory surface receptor expressed by myeloid cells and other tissues, including microglia in the central nervous system, regulating immune cells and inflammation (1). It functions by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2, blocking downstream signal transduction via their SH2 domains (2). Furthermore, PILRA plays a role as an entry co-receptor for herpes simplex virus-1 via binding of viral glycoprotein B1 (3). More recently, mutations in the gene have been implicated in Alzheimer's disease (AD) (1,4). Recent large-scale GWAS have linked the risk of developing late-onset AD in humans harboring rare variants of microglial immunoreceptors such as TREM2, CD33, and PILRA (5). Alternate Names Cell surface receptor FDF03; FDF03; Inhibitory receptor PILR-alpha; inhibitory receptor PILRalpha; paired immunoglobin like type 2 receptor alpha; paired immunoglobin-like receptor alpha; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like receptor alpha; Paired immunoglobulin-like type 2 receptor alpha; PILRA Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 50 Source/Isotype: Rabbit IgG