CST, 48501S, CDKN3 (E7O5K) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying CDKN3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CDKN3 (E7O5K) Rabbit Monoclonal Antibody (CST #48501) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity CDKN3 (E7O5K) Rabbit Monoclonal Antibody recognizes endogenous levels of total CDKN3 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro107 of human CDKN3 protein. Background CDKN3 (Cyclin-Dependent Kinase Inhibitor 3)/KAP (Kinase-Associated Phosphatase) is a dual specificity phosphatase that regulates cell cycle progression through dephosphorylation and inhibition of cyclin-dependent kinases (1). CDKN3 promotes cancer cell proliferation and invasion (2-4), as well as resistance to cisplatin (5,6). Overexpression of CDKN3 is associated with tumor progression and poor prognosis in several human cancers (5-9). Alternate Names CDI1; Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDKN3; CIP2; cyclin dependent kinase inhibitor 3; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; FLJ25787; KAP; KAP1; Kinase-associated phosphatase; MGC70625 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 23 Source/Isotype: Rabbit IgG