CST, 49468S, Visinin-Like Protein 1 (D9L6L) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Visinin-like 1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Visinin-Like Protein 1 (D9L6L) Rabbit Monoclonal Antibody (CST #49468) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Visinin-Like Protein 1 (D9L6L) Rabbit Monoclonal Antibody recognizes endogenous levels of total Visinin-like Protein 1 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg150 of human Visinin-like Protein 1 protein. Background Visinin-like Protein 1, also called VILIP-1 and VSNL1, is a calcium-sensing protein in the central nervous system. Visinin-like Protein 1 exhibits a widespread distribution with high expression in the CNS, and lower expression levels in some peripheral tissues (1). Visinin-like Protein 1 responds to increased intracellular calcium concentration by translocating from the cytoplasm to membranes through calcium-dependent myristoylation at its N-terminus that allows interaction with membranes (2). This change in localization has been proposed to facilitate the activation of compartment-specific signal transduction for the selective activation of downstream signaling cascades (3,4). In Alzheimer's disease, Visinin-like Protein 1 expression is decreased in the brain, including a reduced number of Visinin-like Protein 1 immunoreactive neurons (5); however, the presence of the protein is increased in the CSF (6), suggesting that it is released from neurons during insults. Alternate Names Hippocalcin-like protein 3; HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1; visinin like 1; visinin-like 1; Visinin-like protein 1; VISL1; VLP-1; VSNL1 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 18 Source/Isotype: Rabbit IgG