CST, 51468S, TRAT1 (E3L8A) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TRAT1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TRAT1 (E3L8A) Rabbit Monoclonal Antibody (CST #51468) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity TRAT1 (E3L8A) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRAT1 protein. This antibody detects TRAT1 monomers and homodimers. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRAT1 protein. Background T cell receptor-associated transmembrane adaptor 1 (TRAT1) is a transmembrane adaptor protein, which is expressed as a disulfide-linked homodimer on the surface of cells belonging to the T and NK lineage. Research studies have demonstrated that TRAT1 is associated with the T cell receptor (TCR) signaling complex. Furthermore, T cell activation promotes tyrosine phosphorylation of the TRAT1 cytoplasmic tail, which facilitates the recruitment of SH2 domain-containing signaling proteins known to regulate T cell function (1). TRAT1 may also modulate TCR signaling by stabilizing the surface expression of the TCR signaling complex (2). Alternate Names HSPC062; pp29/30; T cell receptor associated transmembrane adaptor 1; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TCRIM; TRAT1; TRIM Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 28, 60 Source/Isotype: Rabbit IgG