CST, 52170T, IL-33 (F7H4J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IL33 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IL-33 (F7H4J) Rabbit Monoclonal Antibody (CST #52170) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity IL-33 (F7H4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-33 protein. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln205 of mouse IL-33 protein. Background IL-33 (Interleukin-33, NF-HEV) is a nuclear cytokine that is part of the IL-1 family (1,2). Originally discovered as the ‘nuclear factor from high endothelial venules,' it is widely expressed by endothelial cells as well as epithelial barrier tissues (1,5). IL-33 is involved in regulating type 2-associated innate immune responses (2,4). It is the ligand for ST2 which, along with IL-1RAcP, forms the IL-33R signaling complex (2,3). IL-33 functions as an alarmin upon cellular damage or stress, and is associated with allergic inflammation and asthma (5,6). Alternate Names 9230117N10Rik; Il-; IL-33; Il1f; Il1f11; Il33; interleukin 33; Interleukin-33; Interleukin-33(102-266); Interleukin-33(109-266); NF-H; NF-HEV; nuclear factor from high endothelial venules Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 18, 25-30 Source/Isotype: Rabbit IgG