CST, 52181S, CD205/DEC-205 (F1N2F) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying DEC-205. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, CD205/DEC-205 (F1N2F) Rabbit Monoclonal Antibody (CST #52181) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity CD205/DEC-205 (F1N2F) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD205/DEC-205 protein. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CD205/DEC-205 protein. Background DEC-205 (LY75, CD205) is an endocytic type I, C-type lectin-like member of the macrophage mannose receptor family (1-7). It is a type I membrane protein, expressed primarily in dendritic cells and thymic epithelial cells (1-3). DEC-205 mediates the endocytosis of antigens (1-7). Once antigens are broken down, they enter the MHC class I or MHC class II presentation pathways and cross-present to T cells, leading to activation of the immune response (4-7). Alternate Names C-type lectin domain family 13 member B; CD205; CLEC13B; DEC-205; gp200-MR6; Ly-75; LY75; Lymphocyte antigen 75 Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 205 Source/Isotype: Rabbit IgG