CST, 52671S, PVRIG Antibody

Polyclonal Antibody for studying PVRIG. Validated for Western Blotting. Highly specific and rigorously validated in-house, PVRIG Antibody (CST #52671) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PVRIG Antibody recognizes endogenous levels of total PVRIG protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala318 of human PVRIG protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein (PVRIG; also known as CD112 receptor) is a multiple transmembrane protein expressed on the surface of T cells and NK cells, predominantly on memory and effector CD8 T cells. PVRIG expression is upregulated after T cell activation with anti-CD3 and anti-CD28 antibodies. PVRIG competes with DNAM-1/CD226 for interaction with the receptor ligand Nectin-2. Upon ligation of PVRIG and Nectin-2, T cell proliferation is inhibited, suggesting PVRIG is a co-inhibitory receptor that dampens T cell functions (1). Alternate Names C7orf15; CD112 receptor; CD112R; MGC104322; MGC138295; MGC138297; MGC2463; nectin-2 receptor; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVR related immunoglobulin domain containing; PVRIG; Transmembrane protein PVRIG Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 30-40 SOURCE: Rabbit