CST, 53771T, ICA1L (F6I4E) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ICA1L. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ICA1L (F6I4E) Rabbit Monoclonal Antibody (CST #53771) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity ICA1L (F6I4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total ICA1L protein. A band of unknown origin at 21 kDa is detected by western blot. Species Reactivity: Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val134 of human ICA1L protein. Background Islet cell autoantigen 1-like protein (ICA1L) expression is enriched in glutamatergic excitatory neurons (1). ICA1L plays a crucial role in myelination, where it has recently been linked to multiple sclerosis (MS) pathogenesis (2,3). is a newly discovered risk gene for MS but has previously been identified as a risk gene for cerebrovascular disease by several genome-wide association studies (GWAS). Recent proteome-wide association studies (PWAS) found that diseases associated with also include cerebrovascular disease (4-7). Alternate Names ALS2CR14; ALS2CR15; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein; DKFZp434E1919; ICA1L; Ica69-related protein; islet cell autoantigen 1 like; Islet cell autoantigen 1-like protein; islet cell autoantigen 1,69kDa-like; MGC138440 Specification REACTIVITY: M R SENSITIVITY: Endogenous MW (kDa): 55 Source/Isotype: Rabbit IgG