CST, 54007S, Cathepsin H (E6L4W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Cathepsin H mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Cathepsin H (E6L4W) Rabbit Monoclonal Antibody (CST #54007) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Cathepsin H (E6L4W) Rabbit Monoclonal Antibody recognizes endogenous levels of mature cathepsin H protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly309 of mouse cathepsin H protein. Background Cathepsin H (CTSH) is a broadly expressed lysosomal cysteine protease involved in the normal degradation of proteins. CTSH is synthesized as an inactive proenzyme that contains a prodomain and a mature domain, whereupon prodomain removal, the enzyme becomes active (1). High expression of CTSH is found in several cancer types, including thyroid carcinoma (2). CTSH can also process specific proteins, like the cytoskeletal protein talin, to regulate cellular processes, such as the abnormal migration of prostate cancer cells (3). The human gene encoding CSTH is also genetically linked to Alzheimer's disease (4). Alternate Names AL022844; Cat H; CATH; Cathepsin B3; Cathepsin BA; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; Cathepsin H mini chain; Ctsh; OTTMUSP00000029135; Pro-cathepsin H Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 25 Source/Isotype: Rabbit IgG