CST, 5412S, PFKP Antibody

Polyclonal Antibody for studying PFKP. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, PFKP Antibody (CST #5412) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity PFKP Antibody detects endogenous levels of total PFKP protein. Species Reactivity: Human, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PFKP protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis (1). There are three isozymes: muscle-type, liver-type, and platelet-type (2,3). Platelet-type phosphofructokinase (PFKP) is expressed in various cell types (4,5). Research studies have shown that genetic variations in PFKP are associated with individuals born small for gestational age that are prone to obesity and diabetes later in adulthood (6). Alternate Names 6-phosphofructokinase type C; 6-phosphofructokinase, platelet type; ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; FLJ40226; K6PP; PFK-C; PFK-P; PFKAP; PFKF; PFKP; Phosphofructo-1-kinase isozyme C; Phosphofructokinase 1; phosphofructokinase, platelet; Phosphofructokinase, platelet type; Phosphohexokinase Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 80 SOURCE: Rabbit