CST, 54322T, IP6K3 (D9O7J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying IP6K3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, IP6K3 (D9O7J) Rabbit Monoclonal Antibody (CST #54322) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity IP6K3 (D9O7J) Rabbit Monoclonal Antibody recognizes endogenous levels of total IP6K3 protein. This antibody does not cross-react with IP6K1 or IP6K2 proteins. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala140 of human IP6K3 protein. Background Inositol hexakisphosphate kinase 3 (IP6K3) is a member of the inositol hexakisphosphate kinase family (1). These kinases are essential for producing inositol pyrophosphates (1). IP6K3 is highly expressed in the cerebellar Purkinje cells, interacts with adducin and spectrin, and plays an important role in determining the cytoskeletal organization and function of these cells (1). In addition, the expression of IP6K3 increases upon treatment with titanium dioxide nanoparticles suggesting a role for IP6K3 in the genotoxicity caused by these nanoparticles (2). Alternate Names ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; IHPK3; Inositol hexakisphosphate kinase 3; Inositol hexaphosphate kinase 3; InsP6 kinase 3; INSP6K3; IP6K3; MGC102928 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 46 Source/Isotype: Rabbit IgG