CST, 54710S, Presenilin 2 (F7E5Q) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Presenilin-2. Validated for WB,WB,IP,IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, Presenilin 2 (F7E5Q) Rabbit Monoclonal Antibody (CST #54710) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Immunoprecipitation: 1:50 Immunohistochemistry (Paraffin): 1:200 - 1:800 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin) Specificity / Sensitivity Presenilin 2 (F7E5Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total Presenilin 2 protein. This antibody does not cross-react with Presenilin 1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr345 of human Presenilin 2 protein. Background Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3). Alternate Names AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer's disease 3-like; CMD1V; E5-1; presenilin 2; presenilin 2 (Alzheimer disease 4); Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PS2; PSEN2; PSN2; PSNL2; STM-2; STM2 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 23 (C-terminal fragment), 54 (full-length) Source/Isotype: Rabbit IgG