CST, 55598S, Parvalbumin Antibody

Polyclonal Antibody for studying Parvalbumin. Validated for Western Blotting. Highly specific and rigorously validated in-house, Parvalbumin Antibody (CST #55598) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Parvalbumin Antibody recognizes endogenous levels of total parvalbumin protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human parvalbumin protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Parvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium (1). Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity (2,3). Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer's disease, autism spectrum disorder, schizophrenia, and bipolar disorder (4). Alternate Names D22S749; MGC116759; parvalbumin; Parvalbumin alpha; PRVA; PVA; PVALB Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 12 SOURCE: Rabbit