CST, 56016S, Stathmin-2 Antibody

Polyclonal Antibody for studying STMN2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Stathmin-2 Antibody (CST #56016) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Stathmin-2 Antibody recognizes endogenous levels of total Stathmin-2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu173 of human Stathmin-2 protein. Antibodies are purified by peptide affinity chromatography. Background Stathmin is a family of microtubule-destabilizing phosphoproteins that play an important role in regulation of the microtubule cytoskeleton (1). The amino terminus of the protein contains multiple phosphorylation sites and is involved in the promotion of tubulin filament depolymerization. Phosphorylation at these sites inactivates the protein and stabilizes microtubules, regulating cellular processes, such as cell cycle and neuronal axon development (2). Stathmin family members include stathmin, stathmin-2, stathmin-3, and stathmin-4. Interestingly, stathmin-2 protein levels correlate with decreased TDP43 expression, an mRNA-binding protein that mislocalizes and aggregates in patients with the motor neuron disease, amyotrophic lateral sclerosis (ALS) (3). Interestingly, TDP43 directly regulates stathmin-2 expression by regulating RNA splicing, suggesting that altered stathmin-2 expression might serve as a biomarker for disease progression or a therapeutic target. Alternate Names neuron-specific growth-associated protein; neuronal growth-associated protein (silencer element); Protein SCG10; SCG10; SCGN10; SGC10; stathmin 2; Stathmin-2; stathmin-like 2; STMN2; superior cervical ganglia, neural specific 10; Superior cervical ganglion-10 protein Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 21, 23 SOURCE: Rabbit