CST, 56266S, PRSS15/LONP1 (D7L8M) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PRSS15/LONP1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PRSS15/LONP1 (D7L8M) Rabbit Monoclonal Antibody (CST #56266) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PRSS15/LONP1 (D7L8M) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRSS15/LONP1 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe920 of human PRSS15/LONP1 protein. Background PRSS15/LONP1 is an ATP-dependent serine protease that selectively degrades misfolded, misassembled, or damaged proteins in mitochondrial matrix. PRSS15/LONP1 is induced by hypoxic, proteotoxic, and endoplasmic reticulum (ER) stress to support cell survival (1). It has been reported that PRSS15/LONP1 inducibility is decreased during aging and chronic stress (2-4). PRSS15/LONP1 is found to be substantially elevated in lymphoma cells compared to resting or activated B cells, and knock-down or inhibition of PRSS15/LONP1 induces apoptosis in lymphoma cells (5). Mutation in PRSS15/LONP1 is associated with CODAS syndrome, a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies (6). Alternate Names CODASS; hLON; hLON ATP-dependent protease; LON; lon peptidase 1, mitochondrial; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONM; LONP; LONP1; MGC1498; Mitochondrial ATP-dependent protease Lon; mitochondrial lon peptidase 1; mitochondrial lon protease-like protein; PIM1; protease, serine, 15; PRSS15; Serine protease 15 Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 106 Source/Isotype: Rabbit IgG