CST, 57221S, TNFSF15 (D1C8W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying TNFSF15. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TNFSF15 (D1C8W) Rabbit Monoclonal Antibody (CST #57221) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100 μg/ml, 50% glycerol and less than 0.02% sodium azide. Store at -20ºC. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TNFSF15 (D1C8W) Rabbit Monoclonal Antibody recognizes endogenous levels of total human TNFS15 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human TNFSF15 protein. Background TNFSF15 (TL1A), a member of the TNF superfamily of proteins, is a splice variant of the TL1/VEGI gene (1). Endothelial cells, monocytes, macrophages, and dendritic cells express TL1A, which is upregulated by proinflammatory cytokines, microorganisms, and AMPK activation (1-4). TL1A activates the NF-κB and JNK pathways through its receptor, DR3 (1,5). TL1A may function as a costimulatory signal for T cell activation, specifically regulating Th17 cell development and proliferation (1,2,6). Mouse models suggest a role for TL1A as a driver for the inflammation and pathogenesis associated with inflammatory bowel disease (7,8). Alternate Names TL1; TL1A; TNF ligand-related molecule 1; TNF superfamily ligand TL1A; TNF superfamily member 15; TNF15; TNFSF15; TNLG1B; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand 1B; Tumor necrosis factor ligand superfamily member 15; Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form; tumor necrosis factor superfamily member 15; Vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A; VEGI; VEGI192A Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 35 Source/Isotype: Rabbit IgG