CST, 57387T, Thyroglobulin (F5O9B) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying Thyroglobulin. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Thyroglobulin (F5O9B) Rabbit Monoclonal Antibody (CST #57387) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity Thyroglobulin (F5O9B) Rabbit Monoclonal Antibody recognizes endogenous levels of total thyroglobulin protein. Non-specific staining was observed in kidney by immunohistochemistry. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human thyroglobulin protein. Background Thyroglobulin (TG) is a large glycoprotein that is synthesized and secreted by follicle cells in the thyroid. It is the precursor to the thyroid hormones thyroxine (T4), and triiodothyronine (T3), which are essential for normal growth and development and for regulating metabolism. Hormone synthesis is controlled by thyroid stimulating hormone (TSH) produced and secreted by the pituitary gland (1). Thyroglobulin can be used as a tumor marker for certain types of thyroid cancer, particularly papillary and follicular thyroid cancer. These cancers produce thyroglobulin, so elevated levels of thyroglobulin in the blood can indicate the presence of cancer. Thyroglobulin levels can also be used to monitor the effectiveness of thyroid cancer treatment (2). In addition to its role in thyroid cancer, thyroglobulin can also be involved in autoimmune thyroid diseases, such as Hashimoto's thyroiditis and Graves' disease. In these conditions, the body's immune system attacks thyroglobulin, leading to inflammation and damage to the thyroid gland (2). Alternate Names AITD3; TG; TGN; THYG; Thyroglobulin Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 300 Source/Isotype: Rabbit IgG