CST, 57969T, FGL1 (E9X9T) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying FGL1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FGL1 (E9X9T) Rabbit Monoclonal Antibody (CST #57969) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity FGL1 (E9X9T) Rabbit Monoclonal Antibody recognizes endogenous levels of total FGL1 protein. Species Reactivity: Human, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant human FGL1 protein. Background FGL1 (fibrinogen-like protein 1, also known as hepassocin) is a secreted protein mainly expressed in liver and its expression is further enhanced following acute liver injury (1-3). FGL1 null mice have multiple metabolic abnormalities and are more prone to develop hepatocellular carcinoma under certain experimental conditions, suggesting FGL1 has diverse functions (4,5). More recently, FGL1 was found to be highly expressed in human cancer cells and function as an inhibitory ligand for LAG3. Blockade of the FGL1-LAG3 interaction stimulates tumor immunity in mouse models. In addition, a high plasma FGL1 level in human cancer patients is associated with a poor prognosis and resistance to anti-PD-1/PD-L1 immunotherapy (6). Alternate Names FGL1; fibrinogen like 1; fibrinogen-like 1; Fibrinogen-like protein 1; Hepassocin; hepatocellular carcinoma-related sequence; Hepatocyte-derived fibrinogen-related protein 1; HFREP-1; HFREP1; HP-041; HPS; LFIRE-1; LFIRE1; Liver fibrinogen-related protein 1; MGC12455 Specification REACTIVITY: H R SENSITIVITY: Endogenous MW (kDa): 32 Source/Isotype: Rabbit IgG