CST, 57981T, FBXO7 (D8L4E) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying FBXO7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FBXO7 (D8L4E) Rabbit Monoclonal Antibody (CST #57981) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity FBXO7 (D8L4E) Rabbit Monoclonal Antibody recognizes endogenous levels of total FBXO7 protein. This antibody detects two bands bands in human cerebellum, consistent with multiple FBXO7 isoforms generated by alternative splicing. Species Reactivity: Human, Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the N-terminus of human FBXO7 protein. Background F-box only protein 7 (FBXO7) is the substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex mediates ubiquitination and degradation of targeted proteins. Several " " chromosomal loci have been associated with monogeneic forms of PD, including (1). The associated allele for is , which encodes the FBXO7 protein. Mutations in cause early-onset autosomal recessive PD, and alterations in FBXO7 normal function, e.g. the protein degradation process, may contribute to PD etiology (2, 3). Additionally, expression of specific FBXO7 isoforms generated by alternative splicing is linked with PD (4). Alternate Names DKFZp686B08113; F-box only protein 7; F-box protein 7; FBX; FBX07; FBX7; FBXO7; PARK15; PKPS Specification REACTIVITY: H M SENSITIVITY: Endogenous MW (kDa): 65-72 Source/Isotype: Rabbit IgG