CST, 5888T, LATS2 (D83D6) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LATS2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LATS2 (D83D6) Rabbit Monoclonal Antibody (CST #5888) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LATS2 (D83D6) Rabbit Monoclonal Antibody detects transfected levels of total LATS2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LATS2 protein. Background Large tumor suppressor kinase 2 (LATS2) is an AGC kinase of the NDR family of kinases. It is a LATS family tumor suppressor that plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, which is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3-5). Alternate Names FLJ13161; Kinase phosphorylated during mitosis protein; KPM; Large tumor suppressor homolog 2; large tumor suppressor kinase 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Warts-like kinase Specification REACTIVITY: H SENSITIVITY: Transfected Only MW (kDa): 150 Source/Isotype: Rabbit IgG