CST, 59089T, FABP6 (F9U9N) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying FABP6. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FABP6 (F9U9N) Rabbit Monoclonal Antibody (CST #59089) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity FABP6 (F9U9N) Rabbit mAb recognizes endogenous levels of total FABP6 protein. This antibody detects a 130 kDa protein of unknown identity in some cell lines. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val41 of human FABP6 protein. Background Fatty acid-binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones. They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes and are increasingly being understood to play key roles in disease (2). Fatty acid-binding protein 6 (FABP6), also known as ileal bile acid-binding protein (I-BABP), is highly expressed in the ileum, where it binds bile acid and regulates the ileal bile acid transport system (3,4). FABPs play a role in cancer initiation and progression, and FABP6 has been identified as a potential therapeutic target and prognostic marker for multiple cancers (5-7). In a study of tumor immune infiltration in colorectal cancer (CRC), knockdown of FABP6 promoted the recruitment of CD8 T cells via enhancing the immunogenicity of tumor cells and promoting chemokine secretion (8). Alternate Names FABP6; fatty acid binding protein 6; fatty acid binding protein 6, ileal; Fatty acid-binding protein 6; Gastrotropin; GT; I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ileal bile acid binding protein; Ileal lipid-binding protein; ILLBP; illeal lipid-binding protein; Intestinal 15 kDa protein; Intestinal bile acid-binding protein Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 12, 15 Source/Isotype: Rabbit IgG