CST, 59197T, FoxA1/HNF3 alpha (IHC578) Mouse Monoclonal Antibody

Monoclonal Antibody for studying FOXA1. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, FoxA1/HNF3 alpha (IHC578) Mouse Monoclonal Antibody (CST #59197) is ready to ship. Product Usage Information Immunohistochemistry (Paraffin): 1:800 - 1:3200 Storage Supplied in a Tris-based buffer with 1% BSA and less than 0.1% sodium azide. Stable for 24 months when stored at 4°C. Do not aliquot the antibody. Protocol Available protocols: Immunohistochemistry (Paraffin) Specificity / Sensitivity FoxA1/HNF3 alpha (IHC578) Mouse Monoclonal Antibody recognizes endogenous levels of total FoxA1/HNF3α protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to human FoxA1/HNF3α protein. Background Forkhead box protein A1 (FoxA1, HNF3α) is a transcription factor required for the development of endoderm-derived organs, such as liver, lung, and prostate (1). FoxA1 functions as a pioneer factor that is recruited primarily to the distant enhancers to change chromatin structure for transcription in a cell type-specific manner (2,3). The FoxA1 transcription factor is implicated in various diseases, playing a role in hormone-dependent disorders, such as breast and prostate cancers (4). The treatment of relapsing-remitting multiple sclerosis patients with IFN-β results in FoxA1-induced stimulation of a novel population of FoxA1(+) regulatory T cells, suggesting a possible immunosuppressive role for FoxA1 (5). Alternate Names forkhead box A1; Forkhead box protein A1; FOXA1; Hepatocyte nuclear factor 3-alpha; hepatocyte nuclear factor 3, alpha; HNF-3-alpha; HNF-3A; HNF3A; MGC33105; TCF-3A; TCF3A; Transcription factor 3A Specification REACTIVITY: H SENSITIVITY: Endogenous Source/Isotype: Mouse IgG1